New Clues to Alzheimer’s Cause Found in How Fluid Leaves the Brain

Discover the breakthrough research that demystifies the process of cerebrospinal fluid drainage from the brain, which has puzzled scientists for 150 years.

By Sarah White
Jul 24, 2019 1:31 PMAug 15, 2023 12:39 PM
Studying a brain in jar
Studying a brain in jar. (Credit: SubstanceTproductions/Shutterstock)

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Some five ounces of clear fluid fills the spaces between your brain and your skull. This brain juice, or cerebrospinal fluid, cushions against injury, supplies nutrients and clears away waste. Your body can make as much as a pint of fresh stuff every day to replace the old.

But for 150 years, scientists have puzzled over how the used cerebrospinal fluid leaves the brain to make room for more. New research, published Wednesday in Nature, has finally deciphered this brain drain process. As a result, it’s also inching us closer to understanding Alzheimer’s and other neurodegenerative diseases.

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