Long before Alexander Fleming discovered penicillin in 1928, people were using antibiotics to combat infections. In the late 1800s, French physician Ernest Duchesne observed Arab stable boys treating sores with mold growing on saddles. Duchesne took a sample of the fungus, identified it as Penicillium and used it to cure guinea pigs infected with typhoid.
Earlier still, texts from ancient civilizations, including Rome, Egypt and China, discussed the healing powers of moldy bread applied to diseased skin. And prior to written history, there’s reason to believe human ancestors took advantage of many medicinal fungi, plants and other natural agents. The use of natural remedies probably extends back millions of years — long before modern scientists understood the biochemical basis of these medicines.